Category: Yale Journal of Biology and Medicine

YJBM Science News Episode 29

YJBM Science News Episode 29

Does mRNA play a role in cell migration? Can we use therapeutic vaccines to treat cancers like kidney cancer? Join co-hosts Majo and Roxanna in this week’s installment of YJBM Science News as they discuss the most recent Yale-affiliated biomedical and biological research that answers these questions and more!

Papers featured in this episode:
“Resolving the three-dimensional interactome of human accelerated regions during human and chimpanzee neurodevelopment” – http://dx.doi.org/10.1016/j.cell.2025.01.007
https://news.yale.edu/2025/02/06/study-sheds-light-genetic-changes-shaped-human-brain-evolution
“A neoantigen vaccine generates antitumour immunity in renal cell carcinoma” – https://doi.org/10.1038/s41586-024-08507-5
https://medicine.yale.edu/news-article/personalized-therapeutic-vaccine-steers-the-immune-system-to-fight-kidney-cancer/
“G3BP1 ribonucleoprotein complexes regulate focal adhesion protein mobility and cell migration” – https://doi.org/10.1016/j.celrep.2025.115237
https://news.yale.edu/2025/02/13/feet-first-understanding-how-mrna-helps-cells-walk
“A human gut bacterium antagonizes neighboring bacteria by altering their protein-folding ability” – https://doi.org/10.1016/j.chom.2025.01.008
https://westcampus.yale.edu/news/2025-02-04-the-hidden-battle-in-your-gut-how-one-bacterium-outsmarts-its-rivals

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YJBM Science News Podcast: Episode 28

YJBM Science News Podcast: Episode 28

Welcome back to YJBM Science News! Join us as we discuss the recent news in healthcare and science across the Yale community. Today, Roxanna and our new host Majo will share some of the most intriguing topics of the past few weeks, including the use of AI in diagnostics, cannabinoids as pain therapy, and more!

Papers featured in this episode:

“Heart failure risk stratification using artificial intelligence applied to electrocardiogram images: a multinational study” – https://doi.org/10.1093/eurheartj/ehae914
https://medicine.yale.edu/news-article/new-ai-tool-identifies-risk-of-future-heart-failure/

“Nav1.8, an analgesic target for nonpsychotomimetic phytocannabinoids” – https://doi.org/10.1073/pnas.2416886122
https://news.yale.edu/2025/01/21/cannabinoids-offer-new-hope-safe-and-effective-pain-relief

“Neural Variability and Cognitive Control in Individuals With Opioid Use Disorder” – http://doi.org/10.1001/jamanetworkopen.2024.55165
https://news.yale.edu/2025/01/17/opioid-use-disorder-might-lead-sticky-brains

“Atgl-dependent adipocyte lipolysis promotes lipodystrophy and restrains fibrogenic responses during skin fibrosis” – https://doi.org/10.1016/j.jid.2024.12.022
https://news.yale.edu/2025/01/29/fat-cells-play-protective-role-fibrosis-development

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YJBM Viruses and Autoimmunity: Interview with Deputy Editors

YJBM Viruses and Autoimmunity: Interview with Deputy Editors

Get an exclusive, behind-the-scenes look at the newest YJBM issue! In this episode, our host Shivesh Shourya sits down with deputy editors RuthMabel Boytz and Evan Navori to discuss December’s “Viruses and Autoimmunity.” From the earliest planning stages to navigating unexpected challenges, discover how this issue came to life—and gain fresh insights into the fascinating intersection of viruses and autoimmune disease.

Read the “Viruses and Autoimmunity” issue:
https://medicine.yale.edu/news-article/yjbms-december-2024-issue-focuses-on-viruses-and-autoimmunity/

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YJBM Science News Podcast: Episode 27

YJBM Science News Podcast: Episode 27

Welcome to the first YJBM Science News of the 2025, and welcome our new host, Roxanna Altus! Join us as we discuss the recent news in healthcare and science across the Yale community. Today, our hosts Mara and Roxanna will share some of the most intriguing topics of the past few weeks.

Papers featured in the episode:
https://www.nature.com/articles/s41556-024-01574-w
https://doi.org/10.1016/j.cell.2024.11.037
https://www.nature.com/articles/s41467-025-55902-1
https://www.nature.com/articles/s41586-024-08341-9

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How Science Can Shape Policy and Prepare Us for What’s Next: An Interview with Dr. Gonzalo Moratorio

How Science Can Shape Policy and Prepare Us for What’s Next: An Interview with Dr. Gonzalo Moratorio

A few years after the COVID-19 pandemic, we’re still uncovering lessons about how science, communities, and governments can work together to tackle global health challenges. Today, we are joined by Dr. Gonzalo Moratorio, Head of the Experimental Evolution of Viruses Lab at the Institut Pasteur de Montevideo and Associate Professor at the University of the Republic, Uruguay, for a chat about keeping the conversation open between academia and the public, how scientists can shape policymaking, and what the next pandemic might look like.

More about Dr. Moratorio’s research:
https://worldfellows.yale.edu/person/gonzalo-moratorio/
https://pasteur.uy/en/heads-of-labs-and-units/gonzalo-moratorio/

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YJBM Science News Podcast: Episode 26

YJBM Science News Podcast: Episode 26

Welcome to the last YJBM Science News of the 2024! Join us as we discuss the recent news in healthcare and science across the Yale community. Today, our hosts Mara and Samantha will share some of the most intriguing topics of the past few weeks.

Papers featured in the episode:

https://www.nature.com/articles/s41590-024-02023-4

https://www.nature.com/articles/s41467-024-54657-5

https://doi.org/10.1093/cid/ciae559

https://doi.org/10.1016/j.ssmqr.2024.100498

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https://medicine.yale.edu/yjbm/

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Brain and Comparative Medicine: An Interview with Dr. Tamas Horvath

Brain and Comparative Medicine: An Interview with Dr. Tamas Horvath

What is comparative medicine and why is it important for guiding knowledge of human diseases? How does the brain regulate homeostasis of the body? In this episode of the YJBM podcast, our host Amy interviews researcher and professor Dr. Tamas Horvath about the broad and expanding topic of comparative medicine and his research on how neuroendocrine regulation is important in homeostasis and the development of metabolic disorders.

Lessons from the Ovary: An Interview with Dr. Hattie Chung

Lessons from the Ovary: An Interview with Dr. Hattie Chung

What can the intricate world of the ovary teach us about overall health? In this episode, we explore the implications of interdisciplinary research and predictive models on drug development with Dr. Hattie Chung, a recently-joined researcher and faculty member at Yale. Dr. Chung studies diverse biological topics through a systems biology lens through which she fosters collaboration and creativity. Come join us and learn about how her research is revolutionizing and driving scientific breakthroughs.

YJBM Science News Podcast: Episode 25

YJBM Science News Podcast: Episode 25

Welcome to the YJBM Science News! Join us as we discuss the recent news in healthcare and science across the Yale community. Today, our hosts Mara and Samantha will share some of the most intriguing topics of the past few weeks.

Papers featured in the episode:

https://publications.aap.org/pediatrics/article/154/Supplement%203/e2024067043N/199726/The-Circumstances-Surrounding-Fatal-Pediatric

https://www.nature.com/articles/s41586-024-08048-x

https://journals.plos.org/digitalhealth/article?id=10.1371/journal.pdig.0000651

https://www.nature.com/articles/s41586-024-08222-1
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https://medicine.yale.edu/yjbm/

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Stress and the Prefrontal Cortex: An Interview with Dr. Amy Arnsten

Stress and the Prefrontal Cortex: An Interview with Dr. Amy Arnsten

How does stress affect the prefrontal cortex? In this episode of the YJBM podcast, host Delyar Khosroabadi speaks with Dr. Amy Arnsten, Albert E. Kent Professor of Neuroscience and Professor of Psychology. Dr. Arnsten shares the experience that sparked her interest in neuroscience, her journey as an undergraduate creating the first neuroscience major at Brown University, and what drew her to study the prefrontal cortex. She discusses dynamic network connectivity, the mechanism of action of guanfacine, and why prefrontal deficits begin to appear in middle age. Dr. Arnsten also offers fascinating insights on how exercise and a healthy diet can benefit the prefrontal cortex.
Get to know YJBM at: https://medicine.yale.edu/yjbm/

Integrative Medicine issue: https://www.ncbi.nlm.nih.gov/pmc/issues/471502/

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