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This week’s episode of YBJM Science News discusses how our surroundings impact a variety of health outcomes. From air pollutants to sleep quality to pharmacy access and more, join Roxanna and Hanna as they discuss recent Yale-affiliated research in biology and medicine.

Papers featured in this episode and associated links:
“Early-Life Exposure to Air and Light Pollution Linked to Increased Risk of Pediatric Thyroid Cancer” – https://ysph.yale.edu/news-article/early-life-exposure-to-air-and-light-pollution-linked-to-increased-risk-of-pediatric-thyroid-cancer
“Perinatal Exposures to Ambient Fine Particulate Matter and Outdoor Artificial Light at Night and Risk of Pediatric Papillary Thyroid Cancer” – https://doi.org/10.1289/EHP14849
New York Times article on Environmental Health Perspectives journal – https://www.nytimes.com/2025/04/29/science/science-journal-environment-trump.html
“Reduced Deep and REM Sleep Could be Early Markers of Alzheimer’s” – https://medicine.yale.edu/news-article/reduced-deep-and-rem-sleep-could-be-early-markers-of-alzheimers/
“Lower slow wave sleep and rapid eye movement sleep are associated with brain atrophy of AD-vulnerable regions” – https://doi.org/10.5664/jcsm.11630
The Atherosclerosis In the Community Study – https://www5.cscc.unc.edu/aric9/
“Groundbreaking Study Highlights Critical Gap in Global Mental Health Research” – https://medicine.yale.edu/psychiatry/news-article/groundbreaking-study-highlights-critical-gap-in-global-mental-health-research/
“Psychiatric genetics in the diverse landscape of Latin American populations” – https://doi.org/10.1038/s41588-025-02127-z
Latin American Genomics Consortium – https://www.latinamericangenomicsconsortium.org/
“A New Metric to Identify – and Prevent – Pharmacy Deserts” – https://medicine.yale.edu/news-article/a-new-metric-to-identify-prevent-pharmacy-deserts/
“Vulnerability Index Approach to Identify Pharmacy Deserts and Keystone Pharmacies” – https://doi.org/10.1001/jamanetworkopen.2025.0715
“Timing of RSV Immunization Matters for Infant Protection” – https://medicine.yale.edu/news-article/timing-of-rsv-immunization-matters-for-infant-protection/
“Estimated Effectiveness of Nirsevimab Against Respiratory Syncytial Virus” – https://doi.org/10.1001/jamanetworkopen.2025.0380
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Why is a lower impact of COVID-19 seen in children compared to adults? In this episode of the YJBM podcast, co-hosts Delyar Khosroabadi and Amy Guan speak with Timothy Watkins, a graduate student in the laboratory of Dr. Ellen F. Foxman at the Yale School of Medicine. He shares what initially drew him to research and how his journey has evolved across disciplines. Tim also discusses the importance of understanding host-virus interactions, mechanisms underlying heightened nasal innate immunity in children, and some of the challenges he encounters in his work.

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This week’s episode of YBJM Science News tackles two important parts of our bodies: skin and brain. From immune cells to lysosomes to brain networks and more, join co-hosts Majo and Hanna as they break down recent Yale-affiliated biological and biomedical research.
Papers featured in this episode:
Skin Injury May Bring on Food Allergies https://medicine.yale.edu/news-article/skin-injury-may-bring-on-food-allergies/
Skin damage signals mediate allergic sensitization to spatially unlinked antigen https://www.science.org/doi/10.1126/sciimmunol.adn0688
Neutrophils in the Immune System Help Build Healthy Skin
https://medicine.yale.edu/news-article/neutrophils-in-the-immune-system-help-build-healthy-skin/?utm_source=YaleToday&utm_medium=email&utm_campaign=YT_YaleToday-Students_4-7-2025
Matrix-producing neutrophils populate and shield the skin https://www.nature.com/articles/s41586-025-08741-5
Damaged Cell ‘Trash Cans’ May Contribute to Parkinson’s Disease https://medicine.yale.edu/news-article/damaged-cell-trash-cans-may-contribute-to-parkinsons-disease/
The bridge-like lipid transport protein VPS13C/PARK23 mediates ER-lysosome contacts following lysosome damage
https://www.nature.com/articles/s41556-025-01653-6
Understanding the Transition from Early to Chronic Psychosis https://medicine.yale.edu/news-article/understanding-the-transition-from-early-to-chronic-psychosis/
Connectome-based predictive modeling of early and chronic psychosis symptoms https://www.nature.com/articles/s41386-025-02064-9

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This week’s episode of the YJBM Science News podcast is all about papers that identify or help narrow down potential new targets and tools for cancer therapeutics. From protein modifications to autoantibodies to epigenetic markers and more, join co-hosts Majo and Roxanna as they break down recent Yale-affiliated biological and biomedical research.

Papers featured in this episode:
“Turnover atlas of proteome and phosphoproteome across mouse tissues and brain regions” – https://doi.org/10.1016/j.cell.2025.02.021
https://medicine.yale.edu/news-article/protein-turnover-mapping-may-offer-clues-for-alzheimers-cancer-treatment/
“A lupus-derived autoantibody that binds to intracellular RNA activates cGAS-mediated tumor immunity and can deliver RNA into cells” – https://doi.org/10.1126/scisignal.adk3320
https://medicine.yale.edu/news-article/lupus-related-antibody-shows-promise-in-enhancing-cancer-treatment-efficacy/
“BRCA2 prevents PARPi-mediated PARP1 retention to protect RAD51 filaments” – https://doi.org/10.1038/s41586-025-08749-x
https://news.yale.edu/2025/03/26/how-inherited-cancer-risks-can-be-used-effective-personalized-therapy
“An in vivo screen identifies NAT10 as a master regulator of brain metastasis” – https://doi.org/10.1126/sciadv.ads6021
https://medicine.yale.edu/news-article/a-genetic-screen-identifies-a-new-master-regulator-of-brain-metastasis/

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