Secret Signals: How the Body Repairs, Reacts, and Reflects

Secret Signals: How the Body Repairs, Reacts, and Reflects

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This week’s episode of YBJM Science News tackles two important parts of our bodies: skin and brain. From immune cells to lysosomes to brain networks and more, join co-hosts Majo and Hanna as they break down recent Yale-affiliated biological and biomedical research.
Papers featured in this episode:
Skin Injury May Bring on Food Allergies https://medicine.yale.edu/news-article/skin-injury-may-bring-on-food-allergies/
Skin damage signals mediate allergic sensitization to spatially unlinked antigen https://www.science.org/doi/10.1126/sciimmunol.adn0688
Neutrophils in the Immune System Help Build Healthy Skin
https://medicine.yale.edu/news-article/neutrophils-in-the-immune-system-help-build-healthy-skin/?utm_source=YaleToday&utm_medium=email&utm_campaign=YT_YaleToday-Students_4-7-2025
Matrix-producing neutrophils populate and shield the skin https://www.nature.com/articles/s41586-025-08741-5
Damaged Cell ‘Trash Cans’ May Contribute to Parkinson’s Disease https://medicine.yale.edu/news-article/damaged-cell-trash-cans-may-contribute-to-parkinsons-disease/
The bridge-like lipid transport protein VPS13C/PARK23 mediates ER-lysosome contacts following lysosome damage
https://www.nature.com/articles/s41556-025-01653-6
Understanding the Transition from Early to Chronic Psychosis https://medicine.yale.edu/news-article/understanding-the-transition-from-early-to-chronic-psychosis/
Connectome-based predictive modeling of early and chronic psychosis symptoms https://www.nature.com/articles/s41386-025-02064-9

Bulldog Days Live 2025

Bulldog Days Live 2025

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For their third annual Bulldog Days Live episode, Hannah and Mark interview three recently admitted students about how they chose to spend their time in high school. The students share their insights on balancing schoolwork, extracurricular activities, social life, work, family, and everything else on their path to applying to college. Admissions officers Skylar and John discuss how the admissions office produces an action-packed three-day campus preview program, including two world-class performance showcases. Hannah and Mark also share dozens of pearls of wisdom submitted by audience members about prioritizing commitments and finding balance.

Anesthesiologist’s role in trauma-informed care

Anesthesiologist’s role in trauma-informed care

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In this episode, Dr. Blake Mergler, Dr. Reid Mergler, and Dr. Caoimhe Duffy examine the crucial role of anesthesiologists in recognizing and addressing trauma during labor. Their thorough narrative review highlights the importance of trauma-informed care, which shifts the focus from “what is wrong with the patient” to “what has happened to the patient.” The trio discusses how anesthesiologists can embrace this mindset, promoting empathy and understanding without judgment.
https://pubmed.ncbi.nlm.nih.gov/39231043/
https://pubmed.ncbi.nlm.nih.gov/39897428/

From Learning to Leading | Brian Petula | From Corrections to Purpose: Leadership on the Frontline

From Learning to Leading | Brian Petula | From Corrections to Purpose: Leadership on the Frontline

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In this inspiring episode of the Connected Leadership podcast, Peter Boyd sits down with Brian Petula a lawyer, entrepreneur, EMT, and Pennsylvania Department of Corrections officer, who shares his powerful journey from rural roots to a purpose-driven life of service. A former student of the Connected Leadership course, Brian reflects on how the course shaped his leadership style, the importance of living with purpose, and his frontline experience transforming lives in corrections. This conversation is a deep dive into authentic leadership, system change, and human potential.

Anika Singh Lemar Confronts Connecticut’s Housing Crisis

Anika Singh Lemar Confronts Connecticut’s Housing Crisis

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Clinical Professor of Law Anika Singh Lemar talks about the struggle to build more affordable housing in Connecticut and the three clinics she leads at the Law School that work on housing issues. She also discusses her ideas about making it easier to build housing.

https://law.yale.edu/yls-today/news/podcast-anika-singh-lemar-confronts-connecticuts-housing-crisis

YJBM Science News 31: Clues to Cancer Care

YJBM Science News 31: Clues to Cancer Care

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This week’s episode of the YJBM Science News podcast is all about papers that identify or help narrow down potential new targets and tools for cancer therapeutics. From protein modifications to autoantibodies to epigenetic markers and more, join co-hosts Majo and Roxanna as they break down recent Yale-affiliated biological and biomedical research.

Papers featured in this episode:
“Turnover atlas of proteome and phosphoproteome across mouse tissues and brain regions” – https://doi.org/10.1016/j.cell.2025.02.021
https://medicine.yale.edu/news-article/protein-turnover-mapping-may-offer-clues-for-alzheimers-cancer-treatment/
“A lupus-derived autoantibody that binds to intracellular RNA activates cGAS-mediated tumor immunity and can deliver RNA into cells” – https://doi.org/10.1126/scisignal.adk3320
https://medicine.yale.edu/news-article/lupus-related-antibody-shows-promise-in-enhancing-cancer-treatment-efficacy/
“BRCA2 prevents PARPi-mediated PARP1 retention to protect RAD51 filaments” – https://doi.org/10.1038/s41586-025-08749-x
https://news.yale.edu/2025/03/26/how-inherited-cancer-risks-can-be-used-effective-personalized-therapy
“An in vivo screen identifies NAT10 as a master regulator of brain metastasis” – https://doi.org/10.1126/sciadv.ads6021
https://medicine.yale.edu/news-article/a-genetic-screen-identifies-a-new-master-regulator-of-brain-metastasis/

Read more about YJBM at:
https://medicine.yale.edu/yjbm/

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https://www.instagram.com/theyjbm/

The Immunology of Long COVID: An Interview with Dr. Lindsay McAlpine and Dr. Keyla Sá

The Immunology of Long COVID: An Interview with Dr. Lindsay McAlpine and Dr. Keyla Sá

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Why do some individuals continue to experience debilitating neurologic symptoms long after their initial COVID-19 infections? How might our own immune systems be the culprit? In this episode of the YJBM podcast, we learn more about the post-acute infection syndrome known as “long COVID” and the challenges associated with trying to understand its underlying mechanisms. Join co-hosts Shivani and Roxanna as they interview Dr. Lindsay McAlpine and Dr. Keyla Sá, researchers at the Yale University School of Medicine, about their work investigating the pathophysiology of long COVID-associated neurologic symptoms.

Papers/preprints mentioned in this interview:
“Case-Control Study of Individuals With Small Fiber Neuropathy After COVID-19” – https://doi.org/10.1212/NXI.0000000000200244
“A causal link between autoantibodies and neurological symptoms in long COVID” – https://doi.org/10.1101/2024.06.18.24309100

Keep up with Dr. McAlpine’s work:
https://medicine.yale.edu/lab/mcalpine/
https://medicine.yale.edu/neurology/research/covid-mind-study/
https://x.com/mcalpinelabyale
https://bsky.app/profile/drlynseymcalpine.bsky.social

Keep up with Dr. Sá’s work:
https://medicine.yale.edu/lab/iwasaki/
https://x.com/keylas3
https://x.com/VirusesImmunity
https://bsky.app/profile/virusesimmunity.bsky.social

Read more about YJBM at:
https://medicine.yale.edu/yjbm/

Follow us on instagram!
https://www.instagram.com/theyjbm/

From Learning to Leading | Laura Sievert Hesseltine | Continual Forward Progress

From Learning to Leading | Laura Sievert Hesseltine | Continual Forward Progress

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Laura Sievert Hesseltine is the Executive Director of Arts Quincy, the oldest arts council in the U.S., where she champions community engagement and cultural transformation. With a background in corporate marketing and a passion for creativity, Laura shares her journey from leading large-scale retail marketing campaigns to revitalizing the arts sector in rural Illinois. She discusses the power of the arts in shaping communities, the importance of making culture accessible to all, and how she applies business principles to nonprofit leadership. Laura also reflects on connected leadership, continuous learning, and how small, intentional steps can drive meaningful change.