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In this week’s episode of the YJBM Science News podcast, co-hosts Hanna and Roxanna explore papers that take us all around different organs in the body! Can we 3D print functional blood vessels? How does the brain spy on our organs? Find out the answers to these questions and more as we discuss recent Yale-affiliated research in biology and medicine.

Papers featured in this episode:
“Development and deployment of a functional 3D-bioprinted blood vessel”: https://doi.org/10.1038/s41598-025-93276-y
https://medicine.yale.edu/news-article/scientists-successfully-implant-bioprinted-aorta-in-rats/
“Typhoid toxin causes neuropathology by disrupting the blood–brain barrier”:
https://doi.org/10.1038/s41564-025-02000-z
https://news.yale.edu/2025/05/09/how-typhoid-fever-triggers-severe-neurological-symptoms
“Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer”:
https://doi.org/10.1158/0008-5472.CAN-24-0859
https://medicine.yale.edu/news-article/new-study-finds-that-physical-pressure-escalates-liver-cancer-aggression/
“The subfornical organ is a nucleus for gut-derived T cells that regulate behaviour”:
https://doi.org/10.1038/s41586-025-09050-7
https://doi.org/10.1038/d41586-025-01655-2
https://medicine.yale.edu/news-article/t-cells-take-up-residence-in-the-healthy-brain-via-a-gut-fat-brain-axis/

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Get insight into the work that went into the most recent YJBM issue, ‘Kinase Signaling’! In this episode, our hosts Shivesh Shourya and Shivani Dayal speak to this issue’s deputy editors Ingrid Heumann and Rahul Gupta to discuss early challenges in the process of creating this issue, publishing new work in the basic sciences, and future directions in the field of kinase signaling, and what they hope readers take away from this issue.

Read the “Kinase Signalling” issue:
https://medicine.yale.edu/news-article/kinase-signaling-is-focus-of-the-march-2025-yjbm-issue/
Read more about YJBM at:
https://medicine.yale.edu/yjbm/
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This week’s episode of YBJM Science News discusses how our surroundings impact a variety of health outcomes. From air pollutants to sleep quality to pharmacy access and more, join Roxanna and Hanna as they discuss recent Yale-affiliated research in biology and medicine.

Papers featured in this episode and associated links:
“Early-Life Exposure to Air and Light Pollution Linked to Increased Risk of Pediatric Thyroid Cancer” – https://ysph.yale.edu/news-article/early-life-exposure-to-air-and-light-pollution-linked-to-increased-risk-of-pediatric-thyroid-cancer
“Perinatal Exposures to Ambient Fine Particulate Matter and Outdoor Artificial Light at Night and Risk of Pediatric Papillary Thyroid Cancer” – https://doi.org/10.1289/EHP14849
New York Times article on Environmental Health Perspectives journal – https://www.nytimes.com/2025/04/29/science/science-journal-environment-trump.html
“Reduced Deep and REM Sleep Could be Early Markers of Alzheimer’s” – https://medicine.yale.edu/news-article/reduced-deep-and-rem-sleep-could-be-early-markers-of-alzheimers/
“Lower slow wave sleep and rapid eye movement sleep are associated with brain atrophy of AD-vulnerable regions” – https://doi.org/10.5664/jcsm.11630
The Atherosclerosis In the Community Study – https://www5.cscc.unc.edu/aric9/
“Groundbreaking Study Highlights Critical Gap in Global Mental Health Research” – https://medicine.yale.edu/psychiatry/news-article/groundbreaking-study-highlights-critical-gap-in-global-mental-health-research/
“Psychiatric genetics in the diverse landscape of Latin American populations” – https://doi.org/10.1038/s41588-025-02127-z
Latin American Genomics Consortium – https://www.latinamericangenomicsconsortium.org/
“A New Metric to Identify – and Prevent – Pharmacy Deserts” – https://medicine.yale.edu/news-article/a-new-metric-to-identify-prevent-pharmacy-deserts/
“Vulnerability Index Approach to Identify Pharmacy Deserts and Keystone Pharmacies” – https://doi.org/10.1001/jamanetworkopen.2025.0715
“Timing of RSV Immunization Matters for Infant Protection” – https://medicine.yale.edu/news-article/timing-of-rsv-immunization-matters-for-infant-protection/
“Estimated Effectiveness of Nirsevimab Against Respiratory Syncytial Virus” – https://doi.org/10.1001/jamanetworkopen.2025.0380
Read more about YJBM at:
https://medicine.yale.edu/yjbm/

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Why is a lower impact of COVID-19 seen in children compared to adults? In this episode of the YJBM podcast, co-hosts Delyar Khosroabadi and Amy Guan speak with Timothy Watkins, a graduate student in the laboratory of Dr. Ellen F. Foxman at the Yale School of Medicine. He shares what initially drew him to research and how his journey has evolved across disciplines. Tim also discusses the importance of understanding host-virus interactions, mechanisms underlying heightened nasal innate immunity in children, and some of the challenges he encounters in his work.

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This week’s episode of YBJM Science News tackles two important parts of our bodies: skin and brain. From immune cells to lysosomes to brain networks and more, join co-hosts Majo and Hanna as they break down recent Yale-affiliated biological and biomedical research.
Papers featured in this episode:
Skin Injury May Bring on Food Allergies https://medicine.yale.edu/news-article/skin-injury-may-bring-on-food-allergies/
Skin damage signals mediate allergic sensitization to spatially unlinked antigen https://www.science.org/doi/10.1126/sciimmunol.adn0688
Neutrophils in the Immune System Help Build Healthy Skin
https://medicine.yale.edu/news-article/neutrophils-in-the-immune-system-help-build-healthy-skin/?utm_source=YaleToday&utm_medium=email&utm_campaign=YT_YaleToday-Students_4-7-2025
Matrix-producing neutrophils populate and shield the skin https://www.nature.com/articles/s41586-025-08741-5
Damaged Cell ‘Trash Cans’ May Contribute to Parkinson’s Disease https://medicine.yale.edu/news-article/damaged-cell-trash-cans-may-contribute-to-parkinsons-disease/
The bridge-like lipid transport protein VPS13C/PARK23 mediates ER-lysosome contacts following lysosome damage
https://www.nature.com/articles/s41556-025-01653-6
Understanding the Transition from Early to Chronic Psychosis https://medicine.yale.edu/news-article/understanding-the-transition-from-early-to-chronic-psychosis/
Connectome-based predictive modeling of early and chronic psychosis symptoms https://www.nature.com/articles/s41386-025-02064-9

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This week’s episode of the YJBM Science News podcast is all about papers that identify or help narrow down potential new targets and tools for cancer therapeutics. From protein modifications to autoantibodies to epigenetic markers and more, join co-hosts Majo and Roxanna as they break down recent Yale-affiliated biological and biomedical research.

Papers featured in this episode:
“Turnover atlas of proteome and phosphoproteome across mouse tissues and brain regions” – https://doi.org/10.1016/j.cell.2025.02.021
https://medicine.yale.edu/news-article/protein-turnover-mapping-may-offer-clues-for-alzheimers-cancer-treatment/
“A lupus-derived autoantibody that binds to intracellular RNA activates cGAS-mediated tumor immunity and can deliver RNA into cells” – https://doi.org/10.1126/scisignal.adk3320
https://medicine.yale.edu/news-article/lupus-related-antibody-shows-promise-in-enhancing-cancer-treatment-efficacy/
“BRCA2 prevents PARPi-mediated PARP1 retention to protect RAD51 filaments” – https://doi.org/10.1038/s41586-025-08749-x
https://news.yale.edu/2025/03/26/how-inherited-cancer-risks-can-be-used-effective-personalized-therapy
“An in vivo screen identifies NAT10 as a master regulator of brain metastasis” – https://doi.org/10.1126/sciadv.ads6021
https://medicine.yale.edu/news-article/a-genetic-screen-identifies-a-new-master-regulator-of-brain-metastasis/

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Why do some individuals continue to experience debilitating neurologic symptoms long after their initial COVID-19 infections? How might our own immune systems be the culprit? In this episode of the YJBM podcast, we learn more about the post-acute infection syndrome known as “long COVID” and the challenges associated with trying to understand its underlying mechanisms. Join co-hosts Shivani and Roxanna as they interview Dr. Lindsay McAlpine and Dr. Keyla Sá, researchers at the Yale University School of Medicine, about their work investigating the pathophysiology of long COVID-associated neurologic symptoms.

Papers/preprints mentioned in this interview:
“Case-Control Study of Individuals With Small Fiber Neuropathy After COVID-19” – https://doi.org/10.1212/NXI.0000000000200244
“A causal link between autoantibodies and neurological symptoms in long COVID” – https://doi.org/10.1101/2024.06.18.24309100

Keep up with Dr. McAlpine’s work:
https://medicine.yale.edu/lab/mcalpine/
https://medicine.yale.edu/neurology/research/covid-mind-study/
https://x.com/mcalpinelabyale
https://bsky.app/profile/drlynseymcalpine.bsky.social

Keep up with Dr. Sá’s work:
https://medicine.yale.edu/lab/iwasaki/
https://x.com/keylas3
https://x.com/VirusesImmunity
https://bsky.app/profile/virusesimmunity.bsky.social

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https://medicine.yale.edu/yjbm/

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In this week’s installment of YJBM Science News, Majo and Roxanna discuss recent Yale-affiliated research about contraceptives, fertility, and immunology! Can our genetic variants help us predict which birth control method would be the most effective? What can the gut microbiome tell us about the immune systems of multiple sclerosis patients before and after undergoing immunotherapy treatment? Join us as we explore not only the answers to these questions, but also as we learn more about the trials and tribulations of data generation!

Papers featured in this episode:

“Pharmacogenomics of the Etonogestrel Contraceptive Implant: A Genome-Wide Association Study of Steady-State Etonogestrel Concentrations” – https://doi.org/10.1097/og9.0000000000000066
https://medicine.yale.edu/news-article/analyzing-genetics-may-lead-to-better-contraceptive-experiences-for-women/

“Allosteric inhibition of the IZUMO1–JUNO fertilization complex by the naturally occurring antisperm antibody OBF13” – https://doi.org/10.1073/pnas.2425952122
https://news.yale.edu/2025/03/03/scientists-discover-how-naturally-occurring-mechanism-hampers-fertility

“A single-cell atlas of circulating immune cells over the first 2 months of age in extremely premature infants” – https://doi.org/10.1126/scitranslmed.adr0942
https://medicine.yale.edu/news-article/new-insights-into-preterm-infant-immunity-could-inform-care/

“Alterations in Gut Microbiome-Host Relationships After Immune Perturbation in Patients With Multiple Sclerosis” – https://doi.org/10.1212/NXI.0000000000200355
https://medicine.yale.edu/news-article/gut-microbiome-changes-linked-to-multiple-sclerosis-ms-new-study-finds/

Read more about YJBM at:
https://medicine.yale.edu/yjbm/

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Does mRNA play a role in cell migration? Can we use therapeutic vaccines to treat cancers like kidney cancer? Join co-hosts Majo and Roxanna in this week’s installment of YJBM Science News as they discuss the most recent Yale-affiliated biomedical and biological research that answers these questions and more!

Papers featured in this episode:
“Resolving the three-dimensional interactome of human accelerated regions during human and chimpanzee neurodevelopment” – http://dx.doi.org/10.1016/j.cell.2025.01.007
https://news.yale.edu/2025/02/06/study-sheds-light-genetic-changes-shaped-human-brain-evolution
“A neoantigen vaccine generates antitumour immunity in renal cell carcinoma” – https://doi.org/10.1038/s41586-024-08507-5
https://medicine.yale.edu/news-article/personalized-therapeutic-vaccine-steers-the-immune-system-to-fight-kidney-cancer/
“G3BP1 ribonucleoprotein complexes regulate focal adhesion protein mobility and cell migration” – https://doi.org/10.1016/j.celrep.2025.115237
https://news.yale.edu/2025/02/13/feet-first-understanding-how-mrna-helps-cells-walk
“A human gut bacterium antagonizes neighboring bacteria by altering their protein-folding ability” – https://doi.org/10.1016/j.chom.2025.01.008
https://westcampus.yale.edu/news/2025-02-04-the-hidden-battle-in-your-gut-how-one-bacterium-outsmarts-its-rivals

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https://medicine.yale.edu/yjbm/
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https://www.instagram.com/theyjbm/